Course: Pathological Physiology 1

« Back
Course title Pathological Physiology 1
Course code PFY/VAB21
Organizational form of instruction Lecture + Exercise
Level of course Master
Year of study 2
Semester Summer
Number of ECTS credits 6
Language of instruction English
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
Lecturer(s)
  • Petřek Martin, prof. MUDr. CSc.
  • Navrátilová Zdenka, doc. Mgr. Ph.D.
  • Petřková Jana, doc. MUDr. Ph.D.
  • Sikorová Kateřina, Mgr. Ph.D.
Course content
Introduction to the pathological physiology. Environmental risk factors in the development of diseases. Apoptosis, necrosis, inflammation. Patophysiology of pain. Water and salt balance. Acid-base disturbances. Pathophysiology of the immune system. Pathofysiologie of blood elements - disturbance of hemostasis, anaemia. Pathophysiology of GIT - intestine, colon. Pathophysiology of the liver and pancreas. Obesity and malnutrition. Central and peripheral nervous system disorders.

Learning activities and teaching methods
Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook), Methods of Written Work, Projection (static, dynamic)
Learning outcomes
During the course of students acquire knowledge about causes of pathological states, molecular, cellular, organ and systemic mechanisms of pathogenesis of major medical syndromes, symptoms, and diseases. Students study the basic clinical terminology, role of genetic and environmental factors in development of the diseases, general mechanisms of disease development. The course starts with studying the typical pathological processes: cell damage, inflammation, fever, disorders of nutrition macro- and microelements' balance, water and acid-base balance. Later on students acquire knowledge about typical disorders in the blood system and hemostasis. Pathophysiology of digestive system and main neurologic disorders is also taught during the course.
The students are able to evaluate the complex history and laboratory and clinical data that are required to establish the diagnosis, plan therapy, and/or set preventive measures. The students understand the principles of experimental and clinical research. The students are endowed with the multifaceted theoretical background for subsequent clinical studies as well as evidence-based medical practice.
Prerequisites
Completion of all 1st year courses.
HIE/VAB11
----- or -----
HIE/VAB12 and LCH/VAB11 and NAN/VAA12 and CJA/VAB12
----- or -----
CJA/VAB41 and CJA/VAA12
----- or -----
CJA/VAA41 and CJA/VA031 and NAN/VAB12
----- or -----
NAN/VAB13 and KAR/VAB11 and BIO/VAB11
----- or -----
BIO/VA011 and LBF/VAB11
----- or -----
LBF/VA011 and PLE/VAA11
----- or -----
PLE/VAA81 and PLE/VAB11
----- or -----
PLE/VAB81 and PVL/VAB12
----- or -----
PVL/VAB32

Assessment methods and criteria
Mark, Oral exam, Written exam, Essay

Active participation in exercises, passing of written tests during term / credit test.
Recommended literature
  • Grossman, S., Porth, C.M. (2014). Porth's Pathophysiology: Concepts of Altered Health States. Wolters Kluwer Health. Lippincott Williams & Wilkins.
  • McCance, K.L., Huether, S.E. (2018). Pathophysiology.
  • Silbernagl, S., Lang, F., Gay, R., Rothenburger, A. (2016). Color Atlas of Pathophysiology. Thieme.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
Faculty: Faculty of Medicine and Dentistry Study plan (Version): General Medicine (2025) Category: Medical sciences 2 Recommended year of study:2, Recommended semester: Summer