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Main menu for Browse IS/STAG
Course info
KFC / NEK
:
Course description
Department/Unit / Abbreviation
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KFC
/
NEK
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Academic Year
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2024/2025
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Academic Year
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2024/2025
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Title
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Noncovalent Interactions
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Form of course completion
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Exam
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Form of course completion
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Exam
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Accredited / Credits
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Yes,
3
Cred.
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Type of completion
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-
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Type of completion
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-
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Time requirements
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Přednáška
2
[Hours/Week]
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Course credit prior to examination
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No
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Course credit prior to examination
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No
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Automatic acceptance of credit before examination
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No
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Included in study average
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YES
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Language of instruction
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Czech, English
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Occ/max
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Automatic acceptance of credit before examination
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No
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Summer semester
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0 / -
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0 / -
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0 / -
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Included in study average
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YES
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Winter semester
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0 / -
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0 / -
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0 / -
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Repeated registration
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NO
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Repeated registration
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NO
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Timetable
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Yes
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Semester taught
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Winter semester
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Semester taught
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Winter semester
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Minimum (B + C) students
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not determined
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Optional course |
Yes
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Optional course
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Yes
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Language of instruction
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Czech, English
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Internship duration
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0
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No. of hours of on-premise lessons |
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Evaluation scale |
A|B|C|D|E|F |
Periodicity |
každý rok
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Periodicita upřesnění |
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Fundamental theoretical course |
No
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Fundamental course |
No
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Fundamental theoretical course |
No
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Evaluation scale |
A|B|C|D|E|F |
Substituted course
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None
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Preclusive courses
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N/A
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Prerequisite courses
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N/A
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Informally recommended courses
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N/A
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Courses depending on this Course
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N/A
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Histogram of students' grades over the years:
Graphic PNG
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XLS
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Course objectives:
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The subject is focused on non-covalent interactions stabilizing intermolecular complexes play an important role in chemistry and physics and are of key importance in bio-disciplines.
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Requirements on student
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-
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Content
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Virtually all processes in living environment are from the beginning to the end unambiguously controlled by non-covalent interactions. Structure of bimolecules resulting from a delicate balance of the hydrogen bonds, electrostatic, dispersion, repulsion and hydrophobic interactions determines uniquely their function.
1. Origin and description of noncovalent interactions. Covalent and non-covalent interactions. 2. Experimental detection of noncovalent interactions. 3. Quantum chemistry and statistical thermodynamics of non-covalent interactions; static and dynamic view. 4. Computer experiments: molecular dynamics and Monte Carlo. 5. Non-covalent interactions in chemistry and physics. 6. Energy, enthalpy, entropy, free energy. Hydrophobic interactions. 7. Hydrogen bond, improper hydrogen bond, double hydrogen bond. 8. Intermolecular complexes in gas phase. 9. Role of liquid phase and structure of the non-covalent complexes in condensed phase. 10. Non-covalent interactions in bio-disciplines. 11. Structure and function of the nucleic bases, their oligomers, DNA and the complexes of DNA with drugs and xenobiotics. 12. Structure and function of proteins, protein folding. 13. Interactions of proteins with drugs, inhibitors and xenobiotics
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Activities
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Fields of study
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Guarantors and lecturers
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Literature
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Recommended:
Hobza P., Havlas Z. Blue-Shifting Hydrogen Bonds. Chem. Rev. 100, 4253., 2000.
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Recommended:
Hobza P., Zahradník R. Intermolecular Interactions between Medium-Sized Systems. Chem. Rev. 88, 871, 1988.
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Recommended:
Hobza P., Zahradník R. Mezimolekulové komplexy. Academia Praha, 1988.
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Recommended:
Mueller-Dethlefs K., Hobza P. Noncovalent Interactions: A Challenge for Experiment and Theory. Chem. Rev. 100, 143, 2000.
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Recommended:
Hobza P., Šponer J. Structure, Energetics, and Dynamics of the Nucleic Acid Base Paris. Chem. Rev. 99, 3247, 1999.
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On-line library catalogues
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Time requirements
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All forms of study
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Activities
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Time requirements for activity [h]
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Preparation for the Exam
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90
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Total
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90
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Prerequisites - other information about course preconditions |
- |
Competences acquired |
ability to define main concepts, describe non-covalent interactions related to bio-disciplines
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Teaching methods |
- Monologic Lecture(Interpretation, Training)
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Assessment methods |
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