Course: Pathological Physiology 2

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Course title Pathological Physiology 2
Course code PFY/VAA31
Organizational form of instruction Lecture + Exercise
Level of course Master
Year of study 3
Semester Winter
Number of ECTS credits 8
Language of instruction English
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
Lecturer(s)
  • Petřek Martin, prof. MUDr. CSc.
  • Navrátilová Zdenka, doc. Mgr. Ph.D.
  • Petřková Jana, doc. MUDr. Ph.D.
  • Sikorová Kateřina, Mgr. Ph.D.
Course content
Pathophysiology of the respiratory system. Blood gasses. Acute respiratory disturbances. Pulmonary embolism. Pulmonary oedema. RDSs. Pathophysiology of kidney. End-stage renal disease. Kidney failure. Nephritic and nephrotic syndromes. Diabetes mellitus. Acute and chronic complications. Disorders of endocrine system. Oedema - local and global. ECG, heart failure, hypertension, acute circulatory failure.

Learning activities and teaching methods
Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook), Methods of Written Work, Projection (static, dynamic)
Learning outcomes
During the course of study students study common principles of the pathogenesis of the most important disorders of respiratory, cardiovascular, endocrine systems and kidneys, provided with interpretation of typical clinical case studies. Student learn to analyse role of different risk factors in pathogenesis of atherosclerosis, arterial hypertension, bronchial asthma, COPD, diabetes mellitus, kidney failure and other important medical states, comparing common and different pathways in pathogenesis of these states. Etiology, pathogenesis and clinical manifestations of life-threatening states (shock, coma, heart/respiratory/kidney failures) are explained together with main principles of diagnostics, treatment and prophylaxis of the disorders. The students are taught to consider the complex relations between causes, dynamics and progress of diseases and to perceive the integrative essence of medicine.
The students are able to evaluate the complex history and laboratory and clinical data that are required to establish the diagnosis, plan therapy, and/or set preventive measures. The students understand the principles of experimental and clinical research. The students are endowed with the multifaceted theoretical background for subsequent clinical studies as well as evidence-based medicinal practice.
Prerequisites
Completion of courses BIochemistry, Physiology, Anatomy 2, and Histology and Embryology 2.
PFY/VAA11
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PFY/VAB21 and FYZ/VAB12
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FYZ/VAB21 and LCH/VAA20
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LCH/VAA22 and CJA/VAB22
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CJA/VAB42 and HIE/VAA12
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HIE/VAA21 and FYZ/VAA11
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FYZ/VAA21

Assessment methods and criteria
Mark, Oral exam, Written exam, Essay

Active participation in exercises, passing of written tests during term / credit test. Exam (written + oral part).
Recommended literature
  • Grossman, S., Porth, C.M. (2014). Porth's Pathophysiology: Concepts of Altered Health States.
  • McCance, K.L., Huether, S.E. (2018). Pathophysiology: The Biologic Basis for Disease in Adults and Children. Mosby.
  • Silbernagl, S., Lang, F., Gay, R., & Rothenburger, A. (2016). Color Atlas of Pathophysiology.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
Faculty: Faculty of Medicine and Dentistry Study plan (Version): General Medicine (2025) Category: Medical sciences 3 Recommended year of study:3, Recommended semester: Winter