Course: Immunology

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Course title Immunology
Course code KIM/VA031
Organizational form of instruction Lecture + Exercise
Level of course Master
Year of study 3
Semester Summer
Number of ECTS credits 6
Language of instruction English
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
Lecturer(s)
  • Raška Milan, prof. Mgr. MUDr. Ph.D.
  • Hutyrová Beáta, MUDr. Ph.D.
  • Kriegová Eva, doc. Ing. Dr.
  • Mrázek František, prof. MUDr. Ph.D.
  • Křupka Michal, Mgr. Ph.D.
  • Kopřiva František, prof. MUDr. Ph.D.
  • Račanský Mojmír, MUDr.
  • Lepařová Lucie, MUDr.
Course content
Introduction of principles of functioning of the immune system, inherited and antigen specific humoral and cell-mediated immune response, structure of lymphatic system, mechanisms of immune response induction, participating immune cell populations and signalling, genetic basis of antigen specific immune response diversity, HLA molecules, central and peripheral tolerance, mechanisms of induction and regulation of inflammatory response. Explanation of the differences in functioning of systemic and mucosal immune system, mechanisms of immune defense to infection and surveillance of tumor development. Principles of hypersensitivity reactions and clinical examples. Introduction to laboratory immunological investigation, including allergen hypersensitivity investigation, principles of specimens collection from patients, principles of clinical immunology laboratory methods, overview of routinelly investigated immune parameters, indications and their interpretation. HLA polymorphism typing and selected molecular biology methods for investigation in patients with autoimmunity disorders, immune efficiencies or malignancies.

Learning activities and teaching methods
Dialogic Lecture (Discussion, Dialog, Brainstorming), Observation, Demonstration, Projection (static, dynamic), Laboratory Work
Learning outcomes
Students will learn about the immunological mechanisms, clinical manifestations and possibilities of immunologically-mediated therapy and prevention of diseases with an immunologic mechanisms involved, especially allergic, autoimmune, and oncology diseases and immunodeficiencies. Students will learn about the principles of transplantation. In the field of immunological investigation methods, students will deepen their knowledge of differential diagnostic significance and interpretive potential.
Students will learn about the principles of immune system functioning, about clinical manifestations, laboratory investigation and therapy and prevention of diseases with an immunological component, especially allergic, autoimmune and oncologic diseases and immunodeficiences.
Prerequisites
Completion of all theoretical subjects.
PFY/VAA31
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PFY/VAB11 and FAR/VAA32
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FAR/VAB11 and MIK/VAA31
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MIK/VAB11 and FYZ/VAA11
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FYZ/VAA21 and FYZ/VAB21

Assessment methods and criteria
Oral exam

Attendance on all practicals. Credit test. Oral exam.
Recommended literature
  • Goldsby, R.A., Kindt, T.J., Osborne, B.A., Kuby J. (2007). Immunology. New York: W.H.Freeman and Company.
  • Murphy, K. (2008). Janeway's Immunobiology. Taylor Francis Ltd.
  • Rabson, A., Roitt, I., Delves, P. (2004). Really Essential Medical Immunology. Wiley-Blackwell.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
Faculty: Faculty of Medicine and Dentistry Study plan (Version): General Medicine (2025) Category: Medical sciences 3 Recommended year of study:3, Recommended semester: Summer