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Lecturer(s)
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Petřek Martin, prof. MUDr. CSc.
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Ondrůšková Rancová Hana, MUDr.
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Navrátilová Zdenka, doc. Mgr. Ph.D.
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Mateášiková Zuzana, MUDr.
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Veselý Ondřej, MUDr.
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Petřková Jana, doc. MUDr. Ph.D.
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Sikorová Kateřina, Mgr. Ph.D.
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Berková Marie, MUDr. Ph.D.
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Kocourková Lenka, Mgr.
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Course content
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Introduction to the pathological physiology. Environmental risk factors in the development of diseases.Apoptosis, necrosis, inflammation. Patophysiology of pain. Water and salt balance. Acid-base disturbances. Pathophysiology of the immune system. Pathofysiologie of blood elements - disturbance of hemostasis, anaemia. Pathophysiology of GIT - intestine, colon. Pathophysiology of the liver and pancreas. Obesity and malnutrition. Central and peripheral nervous system disorders.
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Learning activities and teaching methods
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Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook), Methods of Written Work, Projection (static, dynamic)
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Learning outcomes
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During the course of students acquire knowledge about causes of pathological states, molecular, cellular, organ and systemic mechanisms of pathogenesis of major medical syndromes, symptoms, and diseases. Students study the basic clinical terminology, role of genetic and environmental factors in development of the diseases, general mechanisms of disease development. The course starts with studying the typical pathological processes: cell damage, inflammation, fever, disorders of nutrition macro- and microelements' balance, water and acid-base balance. Later on, students acquire knowledge about typical disorders in the blood system and hemostasis. Pathophysiology of digestive system and main neurologic disorders is also taught during the course.
The students are able to evaluate the complex history and laboratory and clinical data that are required to establish the diagnosis, plan therapy, and/or set preventive measures. The students understand the principles of experimental and clinical research. The students are endowed with the multifaceted theoretical background for subsequent clinical studies as well as evidence-based medical practice.
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Prerequisites
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Completion of courses "BIochemistry 2", "Normal Anatomy 2", and "Histology and Embryology 2".
CJA/VCB11 and BIO/VC011 and LBF/VC011 and LCH/VCB11 and HIE/VCB12 and KAR/VCB11 and PVL/VCB12 and PLE/VCB11 and NAN/VCB12 and PLE/VCA11 and NAN/VCA12
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Assessment methods and criteria
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Mark, Oral exam, Written exam, Essay
Active participation in exercises, passing of written tests during term / credit test.
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Recommended literature
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Navrátilová, Z., Petřek, M., Veselý, O. (2024). Vybrané kapitoly z patologické fyziologie I. Olomouc: Univerzita Palackého v Olomouci.
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Nečas, E. a kol. (2021). Obecná patologická fyziologie. Praha: Karolinum.
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Nečas, E. a kol. (2019). Patologická fyziologie orgánových systémů. Část II.. Praha: Karolinum.
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Nečas, E. a kol. (2019). Patologická fyziologie orgánových systémů. Část I.. Praha.
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Pávková Goldbergová, M. (2016). Patofyziologie v obrazech. Brno: Masarykova univerzita.
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Silbernagl, S., Lang, F., & Jandová, K. (2012). Atlas patofyziologie. Praha: Grada Publishing.
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