Students will work up total synthesis according to the article which is subsequently presented to the next lesson, ideally in PowerPoint or after conversion to PDF. The content presentation is the introduction of the audience with the particular compound, the retro-synthetic analysis and description of the whole synthesis, including reagents, yieldsand so on. The student must demonstrate that it has the synthesis, or the publication well-rehearsed, as he can expect questions from other students and the teacher. For each synthesis are enclosed tasks that need to be resolved and think about them. The successful solution of tasks need to be done other literature search, or use the attached article and references cited therein, alternatively consult with other students or the teacher. Tasks and solutions must be part of the presentation.All reaction schemes used in the presentation is necessary to paint in ChemDraw or ACD ChemSketch (alternatively another drawing program) and apply formatting ACS Style. Copy schemes from other sources is unacceptable. Processed themes (synthesis): 1. Oseltamivir (Corey), Oseltamivir (Fukuyama), Oseltamivir (Trost) 2. Reserpine (Stroke), Reserpine (Woodward) Strychine (Overman) 3. Strychine (MacMillan) Strychine (Mori) Strychine (Woodward), the design of drugs: inhibitors of kinases 4.Suaveoline, Tacamonine, Tirandamycin B; design the structure of drugs: Alzheimer's disease 5. Trifarienol B, U-106305, Virantmycin, design the structure of drugs: inhibitors of kinases 6. Wodeshiol, Yohimbine, Zaragozic acid, design the structure of drugs: inhibitors of metalloproteinases 7. Ziziphine, custom design and synthesis of natural substances 8. Custom design and synthesis of natural substances (3) 9. Custom design and synthesis of natural substances (3)
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