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Lecturer(s)
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Anzenbacherová Eva, doc. RNDr. CSc.
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Galandáková Adéla, Ing. Ph.D.
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Course content
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1. Key role of acetylcoenzyme A in metabolism. Tricarboxylic acid cycle (Citrate cycle), redox (respiratory) chain, aerobic phosphorylation. 2. Endocrine, paracrine and autocrine regulation of metabolic processes. 3. Metabolism of foreign compounds (xenobiotics). Function of the GIT, liver, kidney. 4. Oxidative stress, radicals, reactive oxygen species, nitric oxide, antioxidants. 5. Biochemistry of solid tissues. Osteosynthesis, osteolysis, osteoporosis. 6. Oral biochemistry Part I. Function of saliva, salivary diagnostics. 7. Oral biochemistry Part II. Saliva biomarkers.
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Learning activities and teaching methods
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Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook), Methods of Written Work, Demonstration, Laboratory Work
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Learning outcomes
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The aim of the subject is to explain theoretical principles of biochemistry and regulation mechanisms of basic metabolic pathways in eukaryotic cells. The emphasis is given on metabolic reaction in digestive organs and connective tissues, on the biochemistry of saliva and on the effect of diet on selected metabolic processes.
Students will acquire an overview of basic metabolic processes occurring in the body, including regulations. They will acquire basic knowledge required for interpretation of biochemical reactions in the buccal cavity and they will learn about the functions of saliva and about the causes of carries. From practical aspect, students will be able to carry out simple biochemical analyses including interpretation of results.
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Prerequisites
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Passing subject Medical chemistry.
LCH/ZAA11 and BIO/ZAB11 and NAN/ZAB11 and CJA/ZAB41 and LBF/ZAB11 and LCH/ZAA21 and CJA/ZAA41 and ST1/ZAA40 and ST1/ZAB40 and ST1/ZAB01 and HIE/ZAB11 and KAR/VAB11
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Assessment methods and criteria
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Mark, Written exam, Essay
100% presence in practicals.
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Recommended literature
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Devlin, T. M. (2010). Textbook of Biochemistry with Clinical Correlations. John Wiley & Sons.
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Champe, P. C., Harvey, R. A., Ferrier, D. R. (2007). Biochemistry. Lippincott Williams & Wilkins.
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