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Lecturer(s)
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Šatka Štefan, Mgr.
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Modrianský Martin, prof. Mgr. Ph.D.
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Hanyk Jiří, Mgr.
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Novotná Renata, Ing. Ph.D.
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Bartek Josef, doc. MUDr. CSc.
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Kosina Pavel, Mgr. Ph.D.
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Ryšavá Alena, Mgr. Ph.D.
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Ulrichová Jitka, prof. RNDr. CSc.
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Vostálová Jitka, doc. RNDr. Ph.D.
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Dostál Zdeněk, Mgr. Ph.D.
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Rajnochová Svobodová Alena, doc. Ing. Ph.D.
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Course content
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Main topics covered within this subject will be: 1. Blood plasma lipids. Lipoprotein metabolism. Disorders of lipoprotein metabolism. 2. Insulin and glucagon metabolism. Effect on metabolism. Pathobiochemistry of lipid and carbohydrate metabolism. 3. Biochemical processes in the digestive tract. 4. Metabolic functions of the liver. Catabolism of heme (tetrapyrroles). 5. Metabolism of xenobiotics and ethanol. Iron and copper metabolism. 6. O2 and CO2 transport. Sodium and potassium homeostasis. Acid-base balance (ABB). 7. Biochemical function of kidneys. Biochemistry of nervous tissue. Biochemistry of neural transmission. 8. Neurosecretion. Cerebrospinal fluid. Neurodegenerative diseases. Biochemistry of vision. 9. Nutrition. Overview of nutrient metabolism under different conditions. 10. Extracellular matrix - proteins. Biochemistry of bone. Osteosynthesis. Biochemistry of connective tissue and skin. 11. Biochemistry of muscle activity. Metabolic processes in the myocardium. 12. Metabolism of calcium, magnesium, phosphate and fluoride. Iodine metabolism. Synthesis of thyroid hormones. 13. Biochemistry of blood elements. The most important proteins of the blood plasma. 14. Biochemical processes in the body - summary.
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Learning activities and teaching methods
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Lecture, Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook), Demonstration, Training in job and motor Skils
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Learning outcomes
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The aim of the subject is to explain the principles of biochemical processes in the organism and the mechanisms of regulation of basic metabolic events. This knowledge is a prerequisite for the interpretation of physiological and pathological processes in the human organism. Students are also guided to practical mastery of simple biochemical analyzes and to the interpretation of laboratory test results.
The student who passes the subject will be equipped with knowledge on basic biochemical pathways and information on regulation of intermediary metabolism. Student will be able to interpret physiological and pathological events in human organism. In practice, student will be able to work according to good laboratory practice rules and to perform basic biochemical tests and to interpret laboratory results.
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Prerequisites
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Successfully passing subjects Medical biology, Normal anatomy, and credit in Biochemistry 1.
KAR/VCB11 and BIO/VC011 and CJA/VCB11 and LBF/VC011 and HIE/VCB12 and LCH/VCB11 and PLE/VCB11 and PVL/VCB12 and NAN/VCA12 and NAN/VCB12 and PLE/VCA11
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Assessment methods and criteria
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Mark, Written exam
100% participation in practical exercises, practical test, written exam.
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Recommended literature
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Burtis, C.A., Ashwood, E.R., Bruns, D.E. (2013). Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Elsevier Health Sciences.
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Crook, M. (2013). Clinical Biochemistry and Metabolic Medicine.
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Kumar, V., Gill, K.D. (2018). Basic Concepts in Clinical Biochemistry: A Practical Guide.
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McMurry, J. (2011). Organic Chemistry with Biological Applications.
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