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Vyučující
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Modrianský Martin, prof. Mgr. Ph.D.
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Franková Jana, doc. Mgr. Ph.D.
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Vrba Jiří, doc. Mgr. Ph.D.
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Zholobenko Aleksey, Ph.D.
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Obsah předmětu
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Atoms, molecules, bonds. Chemical equilibrium. Dispersion systems: solutions, colligative properties of solutions, osmotic pressure. Dispersion systems: colloids, interphases, adsorption. Electrolyte solutions: acids and bases, strong and weak electrolytes, ionization of water, pH, equilibrium constants Kw, Ka, Kb, Ksp, hydrolysis. Electrolyte solutions: ampholytes, titration curves, solubility, slightly soluble compounds. Life and energy, principles of bioenergetics. Reaction rate, enzyme kinetics. Reduction and oxidation, galvanic cells, reduction potentials. Structure of organic molecules Reactivity of organic molecules. Selected organic and bioorganic compounds. Selected organic and bioorganic compounds, polymers. Heterocyclic compounds. Biologically important reactions of organic molecules. Aminoacids and peptides. Saccharides. Lipids. Bioelements, coordination compounds. Toxicity of elements and compounds. Reactive oxygen species, lipoper oxidation, antioxidants, major environmental pollutants. Chemical nomenclature, revision. Chemical calculations - concentration, ionic strength. Chemical calculations - osmotic pressure, solubility, solubility constant. Chemical calculations: equilibria, weak electrolytes, buffers. Chemical calculations: reduction and oxidation rections, energy. Organic chemistry I. Organic chemistry II. Organic chemistry III, bioelements. Test.
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Studijní aktivity a metody výuky
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Přednášení, Monologická (výklad, přednáška, instruktáž), Dialogická (diskuze, rozhovor, brainstorming)
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Výstupy z učení
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The student should learn the principles of biophysical, inorganic, bioinorganic, organic and biorganic chemistry required for the study and understanding of biochemistry. He/she should acquire the basics of chemical reasoning and imagination, such as the concepts of molecular shape, intermolecular forces, equilibrium, energy transfer, structure-activity relationships, as well as thorough knowledge of molecules present in biological systems. From the practical point of view, basic laboratory manipulations should be learned.
The student will be able to evaluate how basic types of inorganic and organic compounds react either with each other or with other biological macromolecules, to predict whether the given compound will/will not adversely affect living systems, and estimate the usefulness of the compound for modulation of metabolic pathways in human body.
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Předpoklady
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Knowledge of basic concepts in chemistry. Skills associated with the use of chemical symbols and terminology.
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Hodnoticí metody a kritéria
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Známkou, Písemná zkouška
100% attendance, measurement protocols completed
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Doporučená literatura
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Dostál, J. (2006). Medical Chemistry II. Bioorganic chemistry. Brno: Masaryk University.
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Dvořáčková, S. a kol. (2007). Calculations in medical chemistry. Olomouc: Palacký University.
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Hein, M., Best, L.R., Pattison, S., Arena, S. (2004). Introduction to General, Organic, and Biochemistry. 8th Edition. Wiley.
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Chang, R., Overby, J. (2010). General Chemistry: The Essential Concepts. McGraw-Hill.
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Táborská, E., Dostál, J. (2010). Overview of chemistry. Brno: Masaryk University.
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Táborská, E. et al. (2006). Medical Chemistry I. General and inorganic chemistry. Brno: Masaryk University.
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