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Lecturer(s)
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Kolínek Jiří, Ing.
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Berka Karel, doc. RNDr. Ph.D.
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Kvítek Libor, prof. RNDr. CSc.
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Course content
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1, Basic concepts, chemical engineering as a tool for translating the chemistry into chemical technologies. Mass balances. Energy balances. 2. Hydromechanical operations. Hydrostatics. Fluid flow, laminar flow, turbulent flow. Transport of fluids, basic types of pumps, pumps and pipes characteristics. 3. Filtration. Fundametals of filtration, classification of filtration, driving force for filtration, filter cycle. Centrifuges, filtering centrifuge. Equipment for filtration. 4.Mixing. Solids mixing, blending. Types of solid-mixing machines. Fluid mixing, types of stirrers, modeling of mixing systems. Mixing equipment. 5. Heat transfer. Three fundamental types of heat transfer: conduction, convection and radiation. Heat conduction, heat transfer. 6. Heat exchangers. Types of heat exchangers, construction of heat exchangers. Cocurrent and countercurrent flow. Evaporation. Evaporators types and application. Examples of equipment for heat transfer. 7. Distillation and rectification. Vapor - liquid equilibrium, Raoult's law. Flash distillation. Multistage distillation, McCabe-Thiele method. Batch distillation, batch distillation with rectification. Equipment for distillation and rectification. 8. Extraction. Solid-liquid extraction, leaching. Liquid-liquid extraction. Single stage, crosscurrent extraction, countercurrent extraction. Leaching equipment, extraction equipment. Solids-drying. Terminology and definition. Periods of drying. Solids drying equipment. 9. Membrane separation processes. Backround and definition. General examples. Microfiltration, ultrafiltration, nanofiltration. Pervaporation. Reverse osmosis. Industrial applications. 10. Reactors. Basic types of reactors, ideal reactors.Microreactor. Equipment. Batch reactor, flow reactoŕ. 11. Mechanical operations. milling, micronization, screening. Equipment: mills, jet mills, screening machines. 12. Fundametals of cGMP (current Good Manufacturing Practice) Process equipment requirements. 13.-14. Visit of Active Pharmaceutical Ingredients facility - 4 hours.
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Learning activities and teaching methods
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Lecture, Demonstration
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Learning outcomes
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To teach the students about basic unit operations and process equipment for chemical technologies, especially for Active Pharmaceutical Ingredients manufacturing. Fundamentals of Good Manufacturing Practice policy will be explained. In the selected cases examples of technological calculations will be demonstrated. The lecture will be targeted more on application in practice than on theoretical fundamentals of chemical engineering. Teaching will be enriched by the production facility visit.
Students get a grounding in basic unit operations used in Chemical Technologies of fine Chemistry. Students get a grouding in cGMP requirements.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral exam
Fundametal knowledge of Physics, Chemistry, Physical Chemistry and Mathematics.
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Recommended literature
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Hasal, P., Schreiber, I., Snita, D. a kol. (2007). Chemické inženýrství I.. VŠCHT Praha, elektronická publikace.
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Míka, V., Neužil, L., Vlček, J. a kol. (1981). Sbírka příkladů z chemického inženýrství. SNTL Praha.
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Perry, R. H., Green, D. W. (1997). Perry's chemical engineers' handbook, 7th ed.. McGraw-Hill.
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