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Lecturer(s)
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Kryštof Vladimír, prof. RNDr. Ph.D.
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Daněk Petr, Mgr. PhD.
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Course content
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Basic characterization and classification of immune cells, surface markers and flow cytometry, ontogeny and hematopoietic differentiation. Distribution of leukocytes in tissues, cellular and molecular aspects of inflammatory processes. Molecular mechanisms of immune cell action in organs, influence of circadian rhythms. Dual role of immune cells - wound healing and regeneration. Role of immune cells in pathological processes and molecular mechanisms of their action. Influence of metabolism and lifestyle on immune cell function, association of local and systemic inflammation with diabetes, metabolic syndrome, low-grade systemic inflammation, molecular basis of these processes. Influence of the microbiome on immune cell function. Hallmarks of cancer, neoantigens, molecular and cellular mechanisms of anti-tumor immune response, tumor microenvironment. Molecular mechanisms of tumor immunosuppression. Immunotherapy - immune checkpoint inhibitors, therapeutic antibodies, therapeutic cytokines, cell-based therapies, biomarkers for immunotherapy deployment, adverse effects of immunotherapies, anti-drug antibodies.
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Learning activities and teaching methods
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Monologic Lecture(Interpretation, Training)
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Learning outcomes
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The aim of the course is to provide students with detailed knowledge of the molecular mechanisms underlying the immune system, focusing on the structure and function of immunoglobulins, T-cell receptors, MHC molecules, and the signaling pathways that regulate immune responses.
The student understands the molecular structure and function of the main components of the immune system, can explain the principles of antigen recognition by B and T lymphocytes, comprehends regulatory mechanisms of immune response and tolerance, is familiar with basic molecular immunology methods (flow cytometry, ELISA, Western blot, recombinant antibodies).
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Prerequisites
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Knowledge of general and cell biology, biochemistry, and basic immunology at the bachelor's level.
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Assessment methods and criteria
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Student performance
Successful completion of the oral exam - discussion on a selected topic
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Recommended literature
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Hořejší V., Bartůňková J. (2017). Základy imunologie. Triton Praha.
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Slabý, O., et al. (2015). Molekulární medicína. Praha Galén.
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