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Lecturer(s)
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Kašpárková Jana, prof. RNDr. Ph.D.
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Course content
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Origin and evolution of life. Cell, cellular organelle. Biological membranes - basic function a structure. Physical properties of biological membranes. Organization of membrane lipids. Phase transitions. Mobility of membrane components. Membrane transport . Basis characteristics of major transport mechanisms. Diffusion. Transfer of ions across membrane. Mediated diffusion (carriers, channels). Active transport. Secondary active transport. Reception and processing of information by membranes. Physical signals. External chemical signals. Molecules of cell surface. Cellular recognition.Receptors, receptor response. Endocytosis mediated by receptors. Cellular adhesion. Cell dynamics: Cytoskeleton. Cellular contacts. Molecular motors. Active motion. Composition and structure of chromosomes. Gene manipulations, recombinant DNA technology.
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Learning activities and teaching methods
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Lecture, Work with Text (with Book, Textbook)
- Homework for Teaching
- 10 hours per semester
- Preparation for the Exam
- 80 hours per semester
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Learning outcomes
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Cell, cellular organelles. Membrane transport, receptors. Cellular dynamics.
Evaluation Evaluate the particular methods and principles, explain the aspects and results concerning the given issue, integrate the knowledge, predict the solutions, evaluate the results and outcomes.
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Prerequisites
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Knowledge of biochemistry, molecular biophysics and molecular biology.
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Assessment methods and criteria
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Oral exam
Knowledge within the scope of the course topics (examination)
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Recommended literature
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Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P., Wilson, J., & Hunt, T. (2008). Molecular biology of the cell. New York, N.Y: Garland Science.
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Bergethon, P. R. (1998). The physical basis of biochemistry: the foundations of molecular biophysics. New York: Springer.
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Creighton, T. E. (2010). The physical and chemical basis of molecular biology. [Great Britain]: Helvetian Press.
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Tuszynski, J. A., & Kurzynski, M. (2003). Introduction to molecular biophysics. Boca Raton: CRC Press.
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