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Lecturer(s)
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Ptáček Jaroslav, Ing. Ph.D.
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Course content
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Introduction, types of ionizing radiation (directly and indirectly ionizing radiation), interactions of directly ionizing radiation with matter, interactions of indirectly ionizing radiation with matter, shielding of ionizing radiation Radioactivity - definition of radioactivity, decay constant, half-life, modes of radioactive decay and their usage in medicine. Detectors of ionizing radiation: gas detectors (ionizing chamber, proportional counter, GM counter), scintillation detectors (organic, inorganic), semiconductor detectors Sources of ionizing radiation in medicine: - radionuclide sources o features o construction - X-ray tubes o principle of operation o contruction o features o energy spectra - linear accelerators o principle of operation o contruction o features Basics of construction and function of imaging systems using ionizing radiation - X-ray machine, CT, scintillation camera, PET. Radiation protection - principles and means of radiation protection, quantities in radiation protection, calculations and estimations of radiation burden. Biological effects of ionizing radiation on human organism - effect of cell irradiation, theory of direct and indirect effects, deterministic and stochastic effects, radiation sickness (acute radiation syndrome)
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Learning activities and teaching methods
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Lecture
- Homework for Teaching
- 20 hours per semester
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Learning outcomes
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Introduction to radiation biology in medicine.
Describe and explain: types of ionizing radiation (directly and indirectly ionizing radiation), interactions of directly ionizing radiation with matter, interactions of indirectly ionizing radiation with matter, shielding of ionizing radiation Radioactivity - definition of radioactivity, decay constant, half-life, modes of radioactive decay and their usage in medicine. Detectors of ionizing radiation: gas detectors (ionizing chamber, proportional counter, GM counter), scintillation detectors (organic, inorganic), semiconductor detectors Sources of ionizing radiation in medicine: - radionuclide sources o features o construction - X-ray tubes o principle of operation o contruction o features o energy spectra - linear accelerators o principle of operation o contruction o features Basics of construction and function of imaging systems using ionizing radiation - X-ray machine, CT, scintillation camera, PET. Radiation protection - principles and means of radiation protection, quantities in radiation protection, calculations and estimations of radiation burden. Biological effects of ionizing radiation on human organism - effect of cell irradiation, theory of direct and indirect effects, deterministic and stochastic effects, radiation sickness (acute radiation syndrome)
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Prerequisites
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unspecified
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Assessment methods and criteria
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Mark
80% fruifulness in exam
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Recommended literature
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Filip, S., Mokrý, J., Hruška, I. (2006). Kmenové buňky. Galén.
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Lanza, R. a spoluautoři. (2004). Handbook of stem cells, Vol. 1+2. Elsevier.
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Odorico, J., Zhang, S.C., Pedersen, R. (2005). Human embryonic stem cells. Garland Science.
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Petr, J. (2003). Klonování, hrozba nebo naděje?. Paseka.
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Thomson, A., McWhir, J. (2004). Gene targeting & Embryonic stem cells. Garland Science.
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