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Lecturer(s)
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Hajdúch Marián, doc. MUDr. Ph.D.
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Schadich Ermin, Ph.D.
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Agrawal Khushboo, Mgr. Ph.D.
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Drábek Jiří, prof. Mgr. Ph.D.
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Srovnal Josef, doc. MUDr. Ph.D.
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Majera Dušana, Mgr. Ph.D.
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Mistrík Martin, Mgr. Ph.D.
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Frydrych Ivo, Mgr. Ph.D.
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Stránská Jana, Mgr. Ph.D.
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Slavkovský Rastislav, Ing. Ph.D.
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Ondková Slavomíra, Ing. Ph.D.
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Varanasi Lakshman, Mgr. Ph.D.
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Gurský Ján, Mgr. PhD.
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Hrstka Roman, doc. Mgr. Ph.D.
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Course content
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The aim of the subject Experimental Medicine is to introduce the student with new important knowledge in the area of molecular medicine, particularly focusing following topics: viruses (DNA, RNA, retroviruses), bacteriophages - structure and replication cycle, the most important enzyme targets, viral and bacterial infections, relationship of viral infections and cancer. Stem cells and their significance in biomedicine. Molecular and genetic origin of mutations. Cellular and molecular processes in transformed cells (mutated, virus or bacteria infected). Molecular alterations in tumor cells. Drug susceptibility/resistance in tumor cells. Molecular basis of immunity (lymphocytes, immunoglobulines, MHC, HLA systems). Applications of molecular biology in diagnostics. Significance and limitations of selected laboratory techniques used in routine diagnostic practice.
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Learning activities and teaching methods
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Lecture
- Homework for Teaching
- 20 hours per semester
- Preparation for the Exam
- 20 hours per semester
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Learning outcomes
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The aim of the subject Experimental Medicine is to introduce the student with new important knowledge in the area of molecular medicine.
Student should be able to (after attending the course): apply new important knowledge in the area of molecular medicine, particularly focusing following topics: viruses (DNA, RNA, retroviruses), bacteriophages - structure and replication cycle, the most important enzyme targets, viral and bacterial infections, relationship of viral infections and cancer. Stem cells and their significance in biomedicine. Molecular and genetic origin of mutations. Cellular and molecular processes in transformed cells (mutated, virus or bacteria infected). Molecular alterations in tumor cells. Drug susceptibility/resistance in tumor cells. Molecular basis of immunity (lymphocytes, immunoglobulines, MHC, HLA systems). Applications of molecular biology in diagnostics. Significance and limitations of selected laboratory techniques used in routine diagnostic practice.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Mark
80% fruitfulness in exam
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Recommended literature
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Časopis Klinická onkologie. vydavatel ČLS JEP - průběžně.
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Časopis Onkológia. vydavatel: Solen, s.r.o. - průběžně.
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Další literatura dle aktuálního výběru přednášejících a studentů.
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Alberts, B. a kol. (2001). Základy buněčné biologie. Espero Publishing, Ústí nad Labem.
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Kolář Z. a kol. (2003). Molekulární patologie nádorů. Epava, Olomouc.
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Nečas, O. (2002). Obecná biologie pro lékařské fakulty. HaH 2000.
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Pecorino L. Molecular Biology of Cancer Mechanisms, Targets, and Therapeutics. Oxford University Press, Velká Británie.
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Rosypal S. Úvod do molekulární biologie. Grafex, Blansko.
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