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Lecturer(s)
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Berka Karel, prof. RNDr. Ph.D.
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Prucek Robert, doc. RNDr. Ph.D.
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Course content
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The importance of kinetics and mechanisms of chemical reactions. Study of equilibrium processes. Acid - basic equilibrium. Generalized Acid function. Study of chemical reactions. Inner and outer factors influencing reactivity. Basic and advanced kinetic equations. Physical and chemical methods of reaction rate determination. Experiment evaluation. Thermodynamics of chemical reactions. Principle of similarity and its application. Salt effects. Bodenstein approximation of quasi-stationar state. Consequent reaction. Superposed equilibrium. Determination of activation parameters of chemical reaction. Classification of solvents and their influential character on the chemical reactivity. Empiric and semi-empiric parameters of solvent polarity. Solvent effects of mixed solvents. Nucleofility and its quantitative description. Isotopic effects. Substitution effects. Bronsted relation. Substitution effects and Hammett equation. Quantitative description of substitution effects based on the effect separation. Application of physical methods in the study of relations between structure and characteristics of organic substances. Application of physical methods in the course of mechanism study of organic reactions. The relationship between the structure of the organic substances and their biological efficiency.
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming)
- Preparation for the Exam
- 0 hours per semester
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Learning outcomes
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The lectures are focused on advanced physical chemistry specialized on reactivity of molecules
ability to integrate knowledge, explain reactivity following physical chemistry
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral exam
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Recommended literature
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Atkins, P., W. (1998). Physical Chemistry.
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Bekárek, V., Nevěčná, T. (1992). Rozpouštědlové vlivy v chemii a jejich hodnocení. Praha.
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Green, P.F. (2004). Transport and Structure in Hard and Soft Materials. CRC Taylor and Francis.
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Hine j.:. (1975). Structural Effects on equilibria in Organic Chemistry,. Wiley&Sons.
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Jungers, J.C. akol. (1963). Chemická kinetika,. Praha.
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Logan, S.R.:. (1996). Fundamentals of Chemical Kinetics,. Longman.
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Masel J.:. (2001). Chemical Kinetics and Catalysis.. John Wiley.
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Štěrba V, Panchartek J. (1985). Kinetické metody při studiu reakcí organických sloučenin. Praha.
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