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Lecturer(s)
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Course content
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Introduction to drug discovery. Interaction of drugs with molecular targets. Fate of drugs in the body - absorbtion, distribution, excretion. Fate of drugs in the body - metabolism. Prodrugs. Identification of active compounds. Natural compounds as drugs and inspiration. Functional groups occurring in active compounds. Strategies o structure modifications. Biotechnology in drug development and production (antibodies, aptamers, siRNA, stem cells ...). Cheminformatics in drug development. Farmacogenomics. Clinical trials. Drug approval. Case studies.
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Learning activities and teaching methods
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Lecture
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Learning outcomes
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Introduction to pharmacology and development of medicaments.
Describe and explain basic principles and strategies of medicinal chemistry.
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Prerequisites
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Introduction to drug discovery. Interaction of drugs with molecular targets. Fate of drugs in the body - absorbtion, distribution, excretion. Fate of drugs in the body - metabolism. Prodrugs. Identification of active compounds. Natural compounds as drugs and inspiration. Functional groups occurring in active compounds. Strategies o structure modifications. Biotechnology in drug development and production (antibodies, aptamers, siRNA, stem cells ...). Cheminformatics in drug development. Farmacogenomics. Clinical trials. Drug approval. Case studies.
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Assessment methods and criteria
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Mark
60% points in test. Discussion of a selected topic in the oral exam.
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Recommended literature
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Amazon.
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Cordes, E.H. Hallelujah Moments. (2014). Tales of Drug Discovery.. Oxford University Press.
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Patrick, G.L. (2013). An Introduction to Medicinal Chemistry. Oxford University Press, USA.
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