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Lecturer(s)
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Raška Milan, prof. Mgr. MUDr. Ph.D.
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Zachová Kateřina, Mgr. Ph.D.
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Kosztyu Petr, Mgr. Ph.D.
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Course content
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Immunology makes acquainted with particular mechanisms of immune response - inherit and adaptive immunity and their humoral and cell components asserting in defense against infection and tumor proliferation. Setting basic immunological terms: humoral immunity, solubility molecules unspecific defense, complement, interferons, antibodies, cell immunity, myelod and lymfoid cell lines of white blood cells (polymorphonuclear leukocytes, fagocytes, dendritic cells, Nk cells, efector and regulation T-lymfocytes, B-lymfocytes, APC), mastocytes, trombocytes, erytrocytes, MHC molecules, cytokines, chemokines, family of TNF proteins, adhesive molecules. Familiarization with principles of activation and regulation of the basic immunological mechanisms is the main aim of the course: inflammation, antigen discrimination, antigen presentation , mechanisms liable for diversity of antibodies and receptor T-lymfocytes, induction of specific immunity response B a T-lymfocytes, immunological memory, regulation T-lymfocytes, importance of PAMP during the induction of immunity response. Immunological statuses: autoimmunity, primary and secondary immunodeficiency, reaction of hypersensitiveness, atopic. In terms of anti -tumor immunity the main accent will be given on mechanisms of immunity control of tumor proliferation by T-lymfocytes, NK cells, ADC, complement. There will be talked over recent immunological methods in diagnostics, in treatment and in prevention of tumor proliferation.
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Learning activities and teaching methods
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Lecture
- Preparation for the Exam
- 25 hours per semester
- Homework for Teaching
- 20 hours per semester
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Learning outcomes
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Immunology makes acquainted with particular mechanisms of immune response - inherit and adaptive immunity and their humoral and cell components asserting in defense against infection and tumor proliferation.
Describe and explain: mechanisms of immune response - inherit and adaptive immunity and their humoral and cell components asserting in defense against infection and tumor proliferation. Setting basic immunological terms: humoral immunity, solubility molecules unspecific defense, complement, interferons, antibodies, cell immunity, myelod and lymfoid cell lines of white blood cells (polymorphonuclear leukocytes, fagocytes, dendritic cells, Nk cells, efector and regulation T-lymfocytes, B-lymfocytes, APC), mastocytes, trombocytes, erytrocytes, MHC molecules, cytokines, chemokines, family of TNF proteins, adhesive molecules. Principles of activation and regulation of the basic immunological mechanisms is the main aim of the course: inflammation, antigen discrimination, antigen presentation , mechanisms liable for diversity of antibodies and receptor T-lymfocytes, induction of specific immunity response B a T-lymfocytes, immunological memory, regulation T-lymfocytes, importance of PAMP during the induction of immunity response. Immunological statuses: autoimmunity, primary and secondary immunodeficiency, reaction of hypersensitiveness, atopic. In terms of anti -tumor immunity the main accent will be given on mechanisms of immunity control of tumor proliferation by T-lymfocytes, NK cells, ADC, complement.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Mark
80% fruitfulness in exam
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Recommended literature
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Abbas, A. K., Lichtman, A. H., Pillai, S. (2007). Cellular and Molecular Immunology. Saunders.
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Bartůňková J., Hořejší V. (2009). Základy imunologie 4. vydání,. Triton.
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Janeway ChA, Travers P, Walport M, Shlomchik MJ. (2005). Immunobiology. Garland Science New York.
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Krejsek J. Kopecký O. (2004). Klinická imunologie. Nucleus HK.
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Raska M., Kasperova A., Krupka M., Raskova Kafkova L., Stuchlova Horynova M., Zachova K. (2013). Imunologické vyšetřovací metody pro studenty LF UP Olomouc. Univerzita Palackého v Olomouci.
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Raska M., Krupka M. (2010). DNA vakcinace ? základní mechanismy indukce imunitní odpovědi.. Univerzita Palackého v Olomouc.
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Roitt I, Brostoff J, Male D. (1998). Immunology. Mosby.
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