|
Lecturer(s)
|
-
Dvořák Zdeněk, prof. RNDr. DrSc.
|
|
Course content
|
Structure and function of proteins. Structure and function of nucleic acids: DNA, mRNA, tRNA, rRNA, ribozymes, small RNA molecules. Genetic code. Genes, transcription, translation, replication. Mechanisms of mutations. DNA repair mechanisms. DNA recombination. Hybridization of nucleic acids, blotting techniques. Polymerase chain reaction. Basic cellular targets. Enzymes - enzyme kinetics, regulation of enzyme activity. Cytoskeleton and its function. Cell signalling - signal molecules, signalling pathways. Receptor theory. Nuclear ans steroid receptors. G-coupled protein receptors - physiological functions, molecular pharmacology functions. Neurotransmitters - nervous system in man, metabolism, mechanism of action, therapeutic potential. Proteasom-ubiqitine system. Metabolism of xenobiotics. Cellular toxicology - mechanisms of cellular damage, repair and defense mechanisms.
|
|
Learning activities and teaching methods
|
|
Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook)
|
|
Learning outcomes
|
Student is aqutainted with the recent knowledge within molecular and cell biology, including used methods and approaches.
Student will be able to: - summarize molecular and cellular biology knowledge - explain molecular and cellular biology techniques - conduct scientific discussion in broader context of the whole discipline
|
|
Prerequisites
|
unspecified
|
|
Assessment methods and criteria
|
Oral exam
Ph.D. exam
|
|
Recommended literature
|
-
Alberts a kol. (2002). Molecular Biology of the Cell. New York.
-
Rang, H.P., Dale, M.M., Ritter, J.M. (2003). Pharmacology. 5th ed., Churchill Livingstone, Edinburgh.
|