|
Lecturer(s)
|
-
Vondráček Jan, prof. RNDr. Ph.D.
|
|
Course content
|
Environmental toxicology is a modern multidisciplinary toxicology discipline, which deals with all aspects of the impact of environmental pollutants on organisms and ecosystems. The program of the course focuses especially on providing an overview of mechanism of action of toxic environmental pollutants on human organism and on vertebrates. At the same time it should provide an overview of basic methodologies used in environmental toxicology for toxicity testing, as well as the analysis of production, transport and accumulation of environmental pollutants. As a part of the course, description of risks, risk analysis and information resources that are necessary for a qualified evaluation of hazards posed by exposure to basic classes of environmental pollutants, will be provided.
|
|
Learning activities and teaching methods
|
|
Lecture
|
|
Learning outcomes
|
Introduction to environmental toxicology, with a specific focus on the mechanisms of toxic action of environmental pollutants, information sources, types of tests and sample preparation..
Following the completion of this course, the students are able to: - describe the toxicity mechanisms of major groups of environmental pollutants, including inorganic gases, heavy metals, pesticides, persistent organic pollutants, polycyclic aromatic hydrocarbons and related heterocyclic compounds, plasticizers, etc., at both cellular and organismal levels; - describe and define basic tests for toxicity of environmental contaminants; - describe and define the mechanisms of production, transport and accumulation of toxic environmental pollutants; - describe and define mechanisms of exposure, toxicokinetics, bioaccumulation and biotransformation of xenobiotics, with a focus on vertebrates; - describe and explain basic principles of risk assessment related to environmental pollution; - have a working knowledge of inforantion resources and organisations dealing with environmental pollution at both national and international levels.
|
|
Prerequisites
|
Foe a successful comletion of the course, it is implied that the students have basic working knowledge of chemistry, biochemistry and biological specializations focused on human health.
|
|
Assessment methods and criteria
|
Didactic Test
50% test
|
|
Recommended literature
|
-
Josephy P.D. a Mannervik B. (2006). Molecular toxicology.
-
Landis, W.G. (2011). Introduction to environmental toxicology: molecular substructures to ecological landscapes.
|