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Lecturer(s)
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Štarha Pavel, doc. Mgr. Ph.D.
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Course content
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1. An overview of biological systems containing transition metal complexes. 2. Advanced methods of studies of structure of biological systems containing transition metal complexes. 3. Types of compounds used as metallotherapeutics derived from various metals (Pt, Ru, Au, Ag, Cu, Zn etc.) and types of their biological activity (cytotoxic, antimicrobial, antimycotic and anti-inflammatory) 4. Types of compounds used as diagnostic (99mTc, 67/68Ga, 111In, 62/64Cu etc.) or therapeutic (198/199Au, 90Y, 153Sm, 166Ho, 67Cu etc.) radiopharmaceuticals. 5. Types of compounds used as contrast agents used for MRI or optical imaging (Mn(II), Gd(III), SPIO etc.) 6. Multimodal contrast agents and theranostics. 7. Design of new ligands and complexes to improve the chemical and biological properties.
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook)
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Learning outcomes
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Knowledge of types of transition metal-based compounds and their functions in biological systems, metal-based drugs and contrast agents used in clinical practice. Modern trends of bioinorganic research of novel metal-based compounds.
Knowledge of functions of transition metals and their compounds in biological systems, and therapeutic and diagnostic agents.
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Prerequisites
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Knowledge of fundamentals of bioinorganic chemistry.
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Assessment methods and criteria
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Written exam
Knowledge of types of transition metal-based compounds and their functions in biological systems, metal-based drugs and contrast agents used in clinical practice. An ability to discuss on a scientific basis.
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Recommended literature
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A. Sigel, H. Sigel. (1996). Metal Ions in Biological Systems, Vol. 32, Interactions of Metal Ions with Nucleotides, Nucleic Acids, and Their Constituents. New York.
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Bertini, J., Gray, H. B., Lippard, S. J., Valentine, J. S. (1994). Bioinorganic Chemistry. California.
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Hay, R. W. (1984). Bio-inorganic Chemistry. Ellis Horwood Limited.
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Housecroft, C. E., Sharpe, A. G. (2022). Anorganická chemie. Praha.
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Kaim, W., Schwederski, B. (1994). Bioinorganic Chemistry: Inorganic Elements in the Chemistry and Life. An Introduction and Guide. John Wiley & Sons Ltd.
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Kraatz, H.-B., Metzler-Nolte, N. (2006). Concepts and Models in Bioinorganic Chemistry. Wiley.
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L. Brown et al. (2018). Chemistry, The Central Science. Londýn.
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M. Gielen, E. R. Tiekink. (2005). Matallotherapeutic Drugs and Metal-based Diagnostic Agents.
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M. Weller et al. (2018). Inorganic Chemistry. New York.
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Vodrážka, Z., Krech, J. (1991). Bioorganická chemie. Praha.
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