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Lecturer(s)
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Štarha Pavel, doc. Mgr. Ph.D.
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Course content
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1. An overview of biological systems containing transition metal complexes. 2. Advanced methods of studies of structure of biological systems containing transition metal complexes. 3. Types of compounds used as metallotherapeutics derived from various metals (Pt, Ru, Au, Ag, Cu, Zn etc.) and types of their biological activity (cytotoxic, antimicrobial, antimycotic and anti-inflammatory) 4. Types of compounds used as diagnostic (99mTc, 67/68Ga, 111In, 62/64Cu etc.) or therapeutic (198/199Au, 90Y, 153Sm, 166Ho, 67Cu etc.) radiopharmaceuticals. 5. Types of compounds used as contrast agents used for MRI or optical imaging (Mn(II), Gd(III), SPIO etc.) 6. Multimodal contrast agents and theranostics. 7. Design of new ligands and complexes to improve the chemical and biological properties.
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook)
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Learning outcomes
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Knowledge of types of transition metal-based compounds and their functions in biological systems, metal-based drugs and contrast agents used in clinical practice. Modern trends of bioinorganic research of novel metal-based compounds.
Knowledge of functions of transition metals and their compounds in biological systems, and therapeutic and diagnostic agents.
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Prerequisites
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Knowledge of fundamentals of bioinorganic chemistry.
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Assessment methods and criteria
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Written exam
Knowledge of types of transition metal-based compounds and their functions in biological systems, metal-based drugs and contrast agents used in clinical practice. An ability to discuss on a scientific basis.
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Recommended literature
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A. Sigel, H. Sigel, E. Freisinger and R. K. O. Sigel (Eds.). (2018). Metallo-Drugs: Development and Action of Anticancer Agents. Metal Ions in Life Sciences Book 18. De Gruyter, 1st ed.
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Dieter Rehder:. (2014). Bioinorganic chemistry. Oxford: Oxford University Press.
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Robert Crichton. (2019). Biological inorganic chemistry : a new introduction to molecular structure and function. London: Academic Press.
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Wolfgang Kaim, Brigitte Schwederski, Axel Klein. (2013). Bioinorganic chemistry : inorganic elements in the chemistry of life: an introduction and guide.. Chichester, United Kingdom: Wiley.
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