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Lecturer(s)
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Drahoš Bohuslav, doc. RNDr. Ph.D.
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Course content
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" nuclear magnetic resonance, the origin, and development of the method " theoretical basics of NMR spectroscopy " excitation and relaxation, chemical shift, coupling constant " experimental aspects of NMR spectroscopy, FT NMR spectrometer, sample, measuring procedure " origin of NMR signal. FID, pulse sequences, decoupling, spectra analysis " 1D NMR spectroscopy, 1H, and 13C NMR spectra, spectroscopy of other nuclei " spin echo, magnetization transfer, Nuclear Overhauser Effect, spectral editing " multidimensional NMR spectroscopy, inverse detection, pulsed-field gradient " homonuclear 2D experiments, COSY, TOCSY, NOESY, INADEQUATE. " heteronuclear 2D experiments, HETCOR, HMQC, HSQC, HMBC " combined experiments and 3D NMR spectroscopy " structure elucidation - analysis of spectra, applications of NMR in chemistry, biochemistry, biology and medicine " NMR spectroscopy of solids, NMR imaging
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Learning activities and teaching methods
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Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming)
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Learning outcomes
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The lecture "NMR spectroscopy" is intended for the first-year students of the master's study of various chemical disciplines. It builds on the bachelor studies of chemistry with the aim to acquaint students with and help them understand the basic principles of nuclear magnetic resonance, instrumental equipment, and modern one- and multi-dimensional techniques of NMR measurements. Interpretation of NMR spectra is an integral part of this course.
Students have knowledge of basic concepts and laws of NMR spectroscopy. They describe the functions of NMR spectrometer and applications of this method in chemistry.
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Prerequisites
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Bachelor's degree in Chemistry (or related field of study).
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Assessment methods and criteria
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Written exam
The student must be able to answer the selected questions and pass the final test with a success rate of more than 70%.
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Recommended literature
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Breitmaier, E. (2002). Structure Elucidation by NMR in Organic Chemistry: A Practical guide. John Wiley & Sons, Chichester, England.
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Buděšínský, M., Pelnař, J. (2000). Fyzikálně-chemické metody. ÚOCHB AV ČR Praha.
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Friebolin, H. (1998). Basic One- and Two-Dimensional NMR Spectroscopy. Wiley VCH, Weinheim, Germany.
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Holík, M. (1983). Čtyři lekce z NMR spektroskopie. PřF MU Brno.
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Lambert, J. B., Mazzola, E. P. (2004). Nuclear Magnetic Resonance Spectroscopy. An Introduction to Principles, Applications, and Experimental Methods. Pearson Education, New Jersey, USA.
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Popa, I., & Novotná, R. (2012). Základy NMR spektroskopie. Olomouc: Univerzita Palackého v Olomouci.
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S. Braun, H. O. Kalinowski, S Berger. (1998). 150 and more basic NMR experiments: a practical course. Wiley VCH, Weinheim, Germany.
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