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Lecturer(s)
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Mohelníková Duchoňová Beatrice, doc. MUDr. Ph.D.
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Course content
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Familial cancer - diagnosis, outputs for practice The sporadic form of cancer - genetic polymorphisms and the cancer risk Signaling pathways and targeted therapy - understanding the effects, indications, side effects Biomarkers of effect and toxicity in chemotherapy - use of pharmacogenomics in practice: - Membrane Transporters - Biotransformation enzymes
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Learning activities and teaching methods
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Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming)
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Learning outcomes
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The course "Molecular Oncology in Clinical Practice" will strengthen the interdisciplinary nature of teaching Oncology and the result will be to integrate the latest scientific knowledge of molecular and cellular biology and clinical practice. The aim of the course is to acquaint students with familial forms of cancer, their diagnosis and outcomes for clinical practice, as well as to get acquainted with the problems and possibilities of genetic polymorphisms and how they influence the risk of cancer sunset. The course focuses on the use of pharmacogenomics in clinical practice, provides an overview of important signaling pathways and their possible influence by target therapies, and biomarkers of effect and toxicity of chemotherapy.
Students will be able to use modern knowledge of molecular biology in the care of patients with malignant tumors.
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Prerequisites
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Passed exam - Biology, Biochemistry, Pathology and Oncology.
ONK/VC011 and LCH/VCA21
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Assessment methods and criteria
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Student performance
100% active participation in seminars
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Recommended literature
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Gelmann, E.P. et al. (2013). Molecular Oncology. Cambridge University.
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Klener, P. a kol. (2013). Principy systémové a protinádorové léčby. Praha Grada.
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