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Lecturer(s)
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Anzenbacherová Eva, doc. RNDr. CSc.
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Jourová Lenka, Mgr. Ph.D.
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Galandáková Adéla, Ing. Ph.D.
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Course content
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1. Biochemistry in dental medicine. Bioenergetics. Localization of biochemical processes in organism. 2. Metabolic processes in the cell and in organelles. Systems of membrane transport. 3. Enzymes. Mechanism of enzyme catalysis. Cofactors/Coenzymes. Enzyme activity, regulation. 4. Overview of the saccharide metabolism in the cell. Metabolism of saccharides in oral cavity. Gluconeogenesis, pentose cycle, metabolism of glycogene. 5. Overview of lipid metabolism. Metabolism of triacylglycerols and fatty acids. Ketogenesis. 6. Proteolysis, overview of amino acid catabolism, biogenic amines, formation of urea. 7. Biochemical processes in gastrointestinal tract (GIT). Utilization of basic nutrients, resorption, biochemistry of mikrobial flora. Influence of diet on oral health.
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Learning activities and teaching methods
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Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook), Methods of Written Work, Demonstration, Laboratory Work
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Learning outcomes
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The aim of the subject is to explain theoretical principles of biochemistry and regulation mechanisms of basic metabolic pathways in eukaryotic cells. The emphasis is given on metabolic reaction in digestive organs and connective tissues, on the biochemistry of saliva and on the effect of diet on selected metabolic processes.
Students will acquire an overview of basic metabolic processes occurring in the body, including regulations. They will acquire basic knowledge required for interpretation of biochemical reactions in the buccal cavity and they will learn about the functions of saliva and about the causes of carries. From practical aspect, students will be able to carry out simple biochemical analyses including interpretation of results.
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Prerequisites
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Passing subject Medical chemistry.
LBF/ZAB11 and LCH/ZAA11 and BIO/ZAA11 and NAN/ZAB11 and CJA/ZAB41 and CJA/ZAA41 and ST1/ZAA40 and ST1/ZAB40 and ST1/ZAB01 and HIE/ZAB11 and KAR/VAB11
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Assessment methods and criteria
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Mark, Written exam, Essay
100% presence in practicals.
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Recommended literature
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Devlin, T. M. (2010). Textbook of Biochemistry with Clinical Correlations. John Wiley & Sons.
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Dvořáčková, S. a kol. (2007). Biochemistry: laboratory classes. Olomouc: Palacký University.
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Champe, P. C., Harvey, R. A., Ferrier, D. R. (2007). Biochemistry. Lippincott Williams & Wilkins.
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