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Lecturer(s)
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Dehner Jan, Mgr.
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Batková Veronika, Mgr.
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Dostálová Kateřina, Mgr. Ph.D.
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Modrianský Martin, prof. Mgr. Ph.D.
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Franková Jana, doc. Mgr. Ph.D.
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Vrba Jiří, doc. Mgr. Ph.D.
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Piskláková Barbora, Mgr.
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Šatka Štefan, Mgr.
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Dobešová Dana, Mgr.
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Přichystalová Hana, Ing. Ph.D.
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Course content
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Atoms, molecules, bonds. Chemical equilibrium. Dispersion systems: solutions, colligative properties of solutions, osmotic pressure. Dispersion systems: colloids, interphases, adsorption. Electrolyte solutions: acids and bases, strong and weak electrolytes, ionization of water, pH, equilibrium constants Kw, Ka, Kb, Ksp, hydrolysis. Electrolyte solutions: ampholytes, titration curves, solubility, slightly soluble compounds. Life and energy, principles of bioenergetics. Reaction rate, enzyme kinetics. Reduction and oxidation, galvanic cells, reduction potentials. Structure of organic molecules Reactivity of organic molecules. Selected organic and bioorganic compounds. Selected organic and bioorganic compounds, polymers. Heterocyclic compounds. Biologically important reactions of organic molecules. Aminoacids and peptides. Saccharides. Lipids. Bioelements, coordination compounds. Toxicity of elements and compounds. Reactive oxygen species, lipoperoxidation, antioxidants, major environmental pollutants. Chemical nomenclature, revision. Chemical calculations - concentration, ionic strength. Chemical calculations - osmotic pressure, solubility, solubility constant. Chemical calculations: equilibria, weak electrolytes, buffers. Chemical calculations: reduction and oxidation rections, energy. Organic chemistry I. Organic chemistry II. Organic chemistry III, bioelements. Test.
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Learning activities and teaching methods
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Lecture, Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming)
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Learning outcomes
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The aim of medical chemistry is to explain the principles of biophysical, inorganic, bioinorganic, organic and bioorganic chemistry required for the study and understanding of biochemistry. Students will acquire the basics of chemical reasoning and imagination, such as the concepts of molecular shape, intermolecular forces, equilibrium, energy transfer, structure-activity relationships, as well as thorough knowledge of molecules present in biological systems. From the practical point of view, students will master simple calculations in stoichiometry, acid-base and oxidation-reduction equilibria, and energy changes in the course of biochemical reactions.
The student will be able to evaluate how basic types of inorganic and organic compounds react either with each other or with other biological macromolecules, to predict whether the given compound will / will not adversely affect living systems, and estimate the usefulness of the compound for modulation of metabolic pathways in human body.
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Prerequisites
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Knowledge of basic concepts in chemistry. Skills associated with the use of chemical symbols and terminology.
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Assessment methods and criteria
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Mark, Written exam
100 % attendance in practicals
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Recommended literature
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Dostál, J. a kol. (2011). Lékařská chemie II: bioorganická chemie. Brno: Masarykova univerzita.
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Dvořáčková, S., Vičar, J., Walterová, D. (2006). Příklady z lékařské chemie a biochemie. Olomouc: Univerzita Palackého Olomouc.
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Franková, J., Modrianský, M., Vrba, J. (2014). Základy lékařské chemie pro studenty všeobecného lékařství. Olomouc: Univerzita Palackého v Olomouci.
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Matouš, B. a kol. (2010). Základy lékařské chemie a biochemie. Praha: Galén.
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Táborská, E. a kol. (2005). Lékařská chemie I: obecná a anorganická chemie. Brno: Masarykova univerzita.
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