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Lecturer(s)
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Přidalová Miroslava, doc. RNDr. Ph.D.
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Course content
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1) General characteristics and structure of living systems - their chemical composition, biogenic elements, water, inorganic substances, saccharides, basic chemical bonds. 2) Lipids, proteins and nucleic acids. 3) Fundamentals of microbiology: prokaryotic cell, bacteria, bacterial disease in humans. 4) Fundamentals of microbiology: eukaryotic cell, structure of a plant and animal cell, cell organelles, cell metabolism. 5) Cell cycle, interphase, nuclear division: amitosis, mitosis and its stages, meiosis, cell division - cytokinesis, cell differentiation and cell death, apoptosis, necrosis. 6) Transcription of genetic information, replication, transcription, translation, gene expression, genetic code. 7) Mutagenesis and teratogenesis. Chromosomal aberrations. Malignant transformation of cells. proto-oncogenes, oncogenes, antioncogenes. 8) Chromosomes, karyotype, cytogenetics and clinical genetics, mutation genotype changes, inheritance in humans, genetic counselling. 9) Mutagenesis and teratogenesis. Chromosomal aberrations. 10) Malignant cell transformation. Proto-oncogenes, oncogenes, antioncogenes. 11) DNA manipulation, biological vector, polymerase chain reaction (PCR), genetic engineering, genetically modified organisms, transgenic plants and animals. 12) Cytoplasmic membrane and its properties. 13) Active and passive transport. Intracellular transport - endoplasmic reticulum, Golgi apparatus. Vesicular transport. Intercellular connections and communication.
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Learning activities and teaching methods
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Monologic Lecture(Interpretation, Training), Work with Text (with Book, Textbook)
- Preparation for the Course Credit
- 13 hours per semester
- Attendace
- 13 hours per semester
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Learning outcomes
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The aim of the course is to introduce to the students the structure and functions of the prokaryotic and eukaryotic cell, present the chemical cell components, energy balance, cell metabolism, inform about the structure and functions of proteins, DNA, and interpret chemical and biochemical terminology from the area of cell biology. In terms of molecular biology the aim of the course is to inform about the details of the journey from DNA to proteins, explain the current theory about chromosomes and gene regulation, genetic variation and genetic engineering technology. An inseparable part of the course is the structure of the membranes, membrane transport, generation of energy, cell compartments and transport. The course explains cell communication, cytoskeleton, cell division, control of the cell cycle and cell death. Information about this course was translated to English within the project Internationalization of the Faculty of Physical Culture, Palacký University, Olomouc, No. CZ.1.07/2.2.00/28.0028, co-funded by the European Social Fund and the Government of the Czech Republic.
In the area of molecular biology, the student is able to explain the details of the journey from DNA to proteins, explain the current theory about chromosomes and gene regulation, genetic variation and genetic engineering technology. The student is able to present the information about the membrane structure, membrane transport, generation of energy, cell compartments and cell transport. The student is able to explain cell communication, basic structure of the cytoskeleton, cell division, control of the cell cycle and cell death. The student is able to distinguish between a eukaryotic and prokaryotic cell.
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Prerequisites
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Grammar school knowledge of human biology and genetics.
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Assessment methods and criteria
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Mark, Student performance
80% attendance, exam - oral or written.
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Recommended literature
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Alberts, B., Bray, D., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P., Kotyk, A., Bouzek, B., & Hozák, P. (2006). Základy buněčné biologie: úvod do molekulární biologie buňky. Ústí nad Labem: Espero.
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Bohmer, D., Danišovič, L., Repinská, V. (2020). Lekárska biológia a genetika 1. Bratislava.
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Campbell, N. A., Reece, J. B., Krebs, C. J., Ridley, M., Minorsky, P. V., Chappell, M. A., Graham, L. E., Bownds, M. D., Niles, M. J., Hardin, J., Allen, G. E., & Moravcová, H. (2006). Biologie. Brno: Computer Press.
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Hesketh Robin. (2023). Introduction to Cancer Biology. Cambridge.
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Nečas, O. et al. (2000). Obecná biologie pro lékařské fakulty. Jinočany: H&H.
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Otová, B., Kohoutová, M., & Panczak, A. (2010). Lékařská biologie a genetika. Praha: Karolinum.
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Panda Satchin. (2020). Cirkadiánní kód. Jan Melvil Publishing.
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Rosypal, S. et al. (2003). Nový přehled biologie. Praha: Scientia.
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Sinclair David. (2020). Konec stárnutí. Jan Melvil Publishing.
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Šmarda, J., Bahbouh, R., Orel, M., Svoboda, M., & Šmahel, Z. Biologie pro psychology a pedagogy.
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Vymětalová, V. (2013). Biologie pro biomedicinské inženýrství: laboratorní cvičení. Praha: ČVUT.
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Vymětalová, V. (2008). Biologie pro biomedicinské inženýrství. Praha: ČVUT.
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Vyskot Boris. (2010). Epigenetika. Olomouc.
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