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Lecturer(s)
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Raška Milan, prof. Mgr. MUDr. Ph.D.
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Braunová Jaroslava, MUDr. Ph.D.
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Hutyrová Beáta, MUDr. Ph.D.
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Heřmanová Zuzana, MUDr. Ph.D.
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Kriegová Eva, doc. Ing. Dr.
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Mrázek František, prof. MUDr. Ph.D.
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Křupka Michal, Mgr. Ph.D.
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Course content
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1. Introduction, definition of the clinical immunology and its relation to other disciplines, history 2. Division of of immune responses by a mechanism affected organ systems, the importance of laboratory diagnostics 3. Autoimmune diseases - symptoms, classification and pathogenesis 4. Autoimmune diseases - diagnosis and treatment, immunosuppression 5. Immunity and Infection, immunity to microorganisms, inflammation and sepsis 6. immunodeficiency - symptoms, sorting, causes 7. immunodeficiency - diagnosis and treatment, substitution therapy 8. Immunomostimulation and immunomodulation, used methods and products, active and passive immunization 9. vaccination, vaccination calendar, legal and social aspects of mandatory vaccinations 10. Transplantation - principles, indications, complications (rejection, GvH) 11. Transplantation - typing of donors and recipients, organization of organ and tissue donation, post-transplant medications 12. Tumor immunity, immunotherapy and immunotyping in oncology, biological drugs 13. Allergology - overview of the clinical units, investigative methods 14. The forms and manifestations of type 1 allergic reactions - food allergies, medication, insect stings, professional allergy. New possibilities for diagnosis and treatment of bronchial asthma. 15. Trends in the antiallergic treatment. Allergen immunotherapy. Anaphylaxis, anaphylactic shock: risk groups, symptoms, treatment. Practical part - clinical seminar - will include examination of the patient with suspected allergy and demonstration of allergy skin tests.
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming), Observation, Demonstration, Projection (static, dynamic), Laboratory Work
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Learning outcomes
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Students will learn about the immunological mechanisms, clinical manifestations and possibilities of immunologically-mediated therapy and prevention of diseases with an immunological component, especially allergic, autoimmune and malignant diseases and immunodeficiency conditions. Will be acquainted with clinical issues of transplantations. In the field of immunological investigation methods, students will deepen their knowledge of their differential diagnostic significance and interpretive potential.
Students will get an overview of pathological conditions in which defects of immune plays a role, diagnostic possibilities including the use of immunological laboratory. Students will obtain an overview about treatment options of immune disorders, whether it's an autoimmune disease, allergy or immunodeficiency. Will become acquainted with immunity aspects of transplantation, will obtain information on the physiological functioning of the immune system and its importance in the defense against bacterial, viral, protozoan, and fungal infections, immunological essence of the clinical manifestations of selected infections and immunologically based possibilities of prevention and therapy. Will be informed about relationship between the immune system and the development of cancer and immunological possibilities of intervention. This knowledge forms an important basis usable in a wide range of specializations of internal medicine and surgery.
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Prerequisites
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Completion all of prescribed exams.
KIM/VAB12 and FAR/VAA12 and PFY/VAB11 and MIK/VAA12 and FAR/VAB11
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Assessment methods and criteria
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Oral exam
100% attendance on all seminars and tutorials, > 80% of the points in the final test is required to obtain the credit.
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Recommended literature
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Murphy K. Janeway´s Immunobiology, 9th Ed.Taylor Francis Ltd..
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Rabson A, Roitt IM, Delves PJ. (2004). Really Essential Immunology. Blackwell Publishing.
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