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Lecturer(s)
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Luhová Lenka, doc. RNDr. Ph.D.
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Course content
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Regulations on the level of cell and intercellular communication. Types of signal molecule and eukaryote intercellular signalisation. Metabolisms of hormons and basic experimental methods for the study of their effect. Mechanisms transmission of signal mediated by surface signals. Heterotrimers transducion G-proteins and their function. Super familly of GTPas and their cell function. Receptors tyrosin-specific kinases (RTK) and MAP kinase specific way. Signalisation mediated by intracellular receptors, mechanisms of effect steroid and thyreoid hormones. Another signal ways, guanylcyklases and NO sthase. Convergency, divergency and crosstalk of various signal wayes. Adaptation target cells, desensitisation of receptors. Receptors ilnesses, ilnesses jointed with disorder transmission of signal. Interaction different hormons at regulation of complex fysiological action.
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming)
- Attendace
- 26 hours per semester
- Preparation for the Exam
- 60 hours per semester
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Learning outcomes
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Generalization of metabolic pathways, methods of metabolism regulation cell trasport systeme and metabolism of glykogene.
Define main concepts, describe main regulating and signal pathways in a cell.
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Prerequisites
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Successful graduation fundamentals of chemistry and mainly fundamentals of biochemistry.
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Assessment methods and criteria
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Written exam
Written exam, 1 hour, 8 tasks; 24 points A 24-22 B 21-18 C 17-16 D 15-14 E 13-12 F less than 12
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Recommended literature
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Berg, J.M., Tymoczko, J.L. and Stryer, L. (2007). Biochemistry. New York, USA.
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Voet D., Voet J. G., Pratt, Ch. W. (2006). Fundamentals of Biochemistry. New York, USA.
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