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Lecturer(s)
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Vrzal Radim, doc. Ing. Ph.D.
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Course content
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History of toxicology, basic concepts in toxicology, absorption, distribution, elimination of toxic compounds, biotransformation. Regulation of biotransformation enzymes, physiological effects on xenobiotics metabolism, organ toxicities (toxicity of the blood, liver toxicity, renal toxicity, neuronal toxicity, dermal, ocular toxicity, lung toxicity, toxicity of immune system, toxicity of reproductive and endocrine system. Mutagenesis, karcinogenesis, teratogenesis. Health risk assessment.
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Learning activities and teaching methods
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Monologic Lecture(Interpretation, Training)
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Learning outcomes
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The subject goal is to introduce the basic concept of toxicology, the effects of toxic agents in particular human body tissues and the molecular mechanisms of selected toxins action.
After the course ending, students is able to: - name types of injured tissues with particular examples of model toxins - explain the molecular mechanism of particular model toxins action - describe the methodology used in the study of toxicology
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Prerequisites
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Basic knowledge of chemistry and human biology
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Assessment methods and criteria
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Written exam
60% test in the extent of the lectures
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Recommended literature
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Boelsterli, UA. (2009). Mechanistic Toxicology, 2nd ed. Informa Healthcare, New York.
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Hodgson, E. (2004). A textbook of modern toxikology, 3rd edition, John Wiley and Sons, New Jersey 2004.
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Klaasen C.D. (2001). Casarett and Doull?s Toxicology: The basic science of poisons, 6th edition. McGraw-Hill Professional.
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Klaassen, Curtis D. (2008). Casarett nad Doull's Toxicology: The basic science of posion, 7th edition. McGraw-Hill.
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