|
Lecturer(s)
|
|
|
|
Course content
|
Molecular structure of biological membrane and transport mechanism across cell membrane. Drug transporters. Pharmacokinetics - single and multiple dose therapy, single and multiply compartment models, bioavailability. Factors influencing drug absorption. Drug distribution - blood brain, barrier, placental barrier, Volume of Distribution. Drug excretion - renal and non renal. Biotransformation of drugs - microsomal, non-microsomal metabolism, factors influencing, enzyme induction and inhibition. Molecular targets of drugs. Theories of drug receptors and drug receptor interactions. Dose-response curve. Cellular and molecular basis of drug action. Second messengers. Signal transduction pathways. Neurotransmitters in CNS. Pharmacogenetics. Targeted therapy.
|
|
Learning activities and teaching methods
|
|
Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook)
|
|
Learning outcomes
|
The main goal for obtaining the exam of Pharmacology in the PhD program of Moleculat and cell biology is to get overview into the effects and mechanism of action of widely prescribed medicaments.
Student will be able to - conduct scientific discussion in broader context of the whole discipline - summarize molecular pharmacology knowledge - explain molecular pharmacology techniques
|
|
Prerequisites
|
unspecified
|
|
Assessment methods and criteria
|
Oral exam
Ph.D. exam
|
|
Recommended literature
|
-
Josephy, D., Mannervik, B. Molecular Toxicology, Academic Press, New York, 2006..
-
Rang, H.P., Dale, M.M., Ritter, J.M. (2003). Pharmacology. 5th ed., Churchill Livingstone, Edinburgh.
|