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Lecturer(s)
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Drahoš Bohuslav, doc. RNDr. Ph.D.
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Course content
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Classic and quantum NMR theory, experimental arrangement. Chemical shift, structure correlations. Spin-spin interaction, relation between interaction constant, shift, and structure of molecule. Intensity of peaks, usage in the analysis. Time of relaxation, relation to the structure, intramolecular movement. Two-dimensional NMR, specials high resolution techniques. Possibility of NMR usage in solutions. Estimation of isomers in the mixture.
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Learning activities and teaching methods
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Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming)
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Learning outcomes
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The lecture "NMR spectroscopy" is intended for Ph.D. students of various chemical disciplines. It builds on the master's studies in chemistry with the aim to obtain an advanced understanding of the principles of nuclear magnetic resonance on the basis of classical physics and quantum mechanics. With the aim to use modern one- and multi-dimensional techniques of NMR measurements to study the structure of organic compounds and complexes, to study the modes of ligand coordination and dynamic processes.
Analyze 1D and 2D high-resolution NMR spectra to obtain information about structure and dynamics. Comparison of NMR spectra of complexes and ligands to obtain information about the type of coordination. Calculation of chemical shifts, interaction constants, integration intensities, relaxation times, etc.
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Prerequisites
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Master's degree in Chemistry (or related field of study).
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Assessment methods and criteria
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Oral exam
For successful completion, the student must be able to answer the questions in the discussion.
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Recommended literature
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Akitt, J. W. (1992). NMR and Chemistry: An Introduction to Modern NMR Spectroscopy. 3. vydání, Chapman and Hall, Londýn.
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Derome, E. (1997). Modern NMR techniques for chemistry research. Pergamon Press, Oxford.
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Gunther, H. (1995). NMR Spectroscopy. Wiley, New York.
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Martin, G. E., Zektzer, A. S. (1998). Two-Dimensional NMR Methods for Establishing Molecular Connectivity. VCH, New York.
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Sanders, J. K. M., Hunter, B. K. (1993). Modern NMR Spectroscopy. Wiley, Oxford.
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