Fundametals of inorganic biochemistry - formal oxidation states and coordination, geometries of biologically important metal ions, classification of metal ions and ligands. Transport and storage - metal ion uptake and transmembrane ion transport. Selected experimental techniques. Metalloproteins and metalloenzymes - oxygen carriers, heme and non-heme iron proteins. Nickel-containing enzymes. Copper-containing proteins. Biological functions of the "early" transition metals (Cr, Mo, W, V). Overview of the biological chemistry of alkali and alkaline earth metal cations. Biological functions of the nonmetallic inorganic elements. Biologically important transition metal complexes (Pt, Ru, Cu ?). In vitro and in vivo biological testing.
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Gielen, M., Tiekink, E. R. T. (2005). Matallotherapeutic Drugs and Metal-based diagnostic agents: The use of Metals in Medicine. John Wiley & Sons, Ltd, Chichester.
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Kaim, W., Schwederski, B. (1994). Bioinorganic Chemistry: Inorganic Elements in the Chemistry and Life. An Introduction and Guide. John Wiley & Sons Ltd.
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Sigel, A., Sigel, H. (1996). Metal Ions in Biological Systems, Vol. 32, Interactions of Metal Ions with Nucleotides, Nucleic Acids, and Their Constituents. Marcel Dekker, Inc., New York.
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