Course: Bioinorganic Chemistry 2

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Course title Bioinorganic Chemistry 2
Course code AFC/BACH2
Organizational form of instruction Lecture
Level of course Master
Year of study not specified
Semester Winter
Number of ECTS credits 3
Language of instruction Czech
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Lecturer(s)
  • Herchel Radovan, doc. Ing. Ph.D.
  • Kopel Pavel, prof. RNDr. Ph.D.
Course content
1. Metal ions in biological systems (transport and storage) and their bonds in active sites of biomolecules. 2. Biological function of non-metallic inorganic elements (B, SI, As, Br, I), bioinorganic chemistry of toxic metals (Pb, Cd, Tl, Hg, Al, Be, Cr(VI)). 3. Metals as centres for photosynthesis (Mn, Mg) 4. Metals in medicine (complexes based on Pt, Ru, Ga, Ti, As, Ti, Au, ..), radiodiagnostic and radiopharmaceutical agents (Tc, Gd,?). 5. Enzymes containing transition metals - nickel (urease, Ni/Fe-hydrogenases, CO-dehydrogenase, copper-containing proteins, biological function of Mo, W, V, and Cr). 6. Biochemical behaviour of inorganic radionuclides and their application in diagnostics and therapy, chemotherapy using compounds of selected non-essential elements.

Learning activities and teaching methods
Lecture
Learning outcomes
The lecture introduces students to basic concepts of Bioinorganic Chemistry and biological function of selected chemical elements.
Recall basic concepts of bioinorganic chemistry. Describe biological functions of the inorganic elements.
Prerequisites
unspecified

Assessment methods and criteria
Oral exam

Exam according syllabus.
Recommended literature
  • Bertini, I., Gray, H. B., Stiefel, E. I., Valentine, J. S. (2007). Biological Inorganic Chemistry, Structure and Reactivity. University Science Books, Sausalito, California.
  • Bertini, J., Gray, H. B., Lippard, S. J., Valentine J. S. (1994). Bioinorganic Chemistry. University Science Books, Sausalito, California.
  • Clarke, M. J., Sadler, P. J. (1999). Metallopharmaceuticals I, DNA interactions. Springer.
  • Cowan, J. A. (1993). Inorganic Biochemistry. An Introduction. VCH Publishers, Inc.
  • Eichhorn, G. L. and Marzilli, L. G. (Eds.). (1994). Models in Inorganic Chemistry, Vol. 9. PTR Prentice Hall Inc., Englewood Cliffs, New Jersey 07632.
  • Gielen, M., Tiekink, E. R. T. (2005). Matallotherapeutic Drugs and Metal-based diagnostic agents: The use of Metals in Medicine. John Wiley & Sons, Ltd, Chichester.
  • Hay, R. W. (1984). Bio-inorganic Chemistry. Ellis Horwood Limited.
  • Kaim, W., Schwederski, B. (1994). Bioinorganic Chemistry: Inorganic Elements in the Chemistry and Life. An Introduction and Guide. John Wiley & Sons Ltd.
  • Kraatz, H.-B., Metzler-Nolte, N. (2006). Concepts and Models in Bioinorganic Chemistry. Wiley-VCH.
  • Lippard, S. J., Berg, J. M. (1994). Principles of Bioinorganic Chemistry. University Science Books.
  • Niccolini, M., Sindellari, L. (1991). Lectures in Bioinorganic Chemistry. Raven Press, New York.
  • Sigel, A., Sigel, H. (1996). Metal Ions in Biological Systems, Vol. 32, Interactions of Metal Ions with Nucleotides, Nucleic Acids, and Their Constituents. Marcel Dekker, Inc., New York.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
Faculty: Faculty of Science Study plan (Version): Inorganic and Bioinorganic Chemistry - specialization in Bioinorganic Chemistry (2021) Category: Chemistry courses 1 Recommended year of study:1, Recommended semester: Winter