The lectures in Inorganic Metallotherapeutics are aimed at students' acquisition of common knowledge about a wide range of medicinal drugs and therapeutics that are not only of organic origin. The discussed compounds contain in their structure a metallic (transition metals, alkali metals?) or non-metallic heteroatom, e.g. boron, selenium, silicon. The lecture is divided into several parts: 1. Introduction into inorganic metallotherapeutics - basic terms, pharmacology, classification of pharmaceuticals, medical forms, correlation between dosage and therapeutic effect, parameters of therapeutic activity and toxicity. Pre-clinical and clinical drug testing. Current situation in research and development of metallotherapeutics. 2. Pharmaceuticals of 1st and 2nd group metals (Li, Mg, Ca) - lithium metallotherapeutics, psychological dysfunctions, schizophrenia, Alzheimer's disease. Magnesium and calcium therapeutics, cardiovascular diseases (treatment of arrhythmia, stroke), osteoporosis. 3. Pharmaceuticals of 13th group metals (B, Al, Ga) - boron compounds (BNCT -boron neutron capture therapy), chemistry of boranes and carboranes. Aluminium metallotherapeutics (adjuvants, antacids), aluminium toxicity. Cancerostatic effect of gallium compounds. 4. Pharmaceuticals of 14th group elements (Si, Ge, Sn) - silicon therapeutics, organosilicates, organometallic compounds of Ge and Sn and their potential cytotoxicity. 5. Pharmaceuticals of 14th and 15th group elements (As, Sb, Bi, Se) - arsenic therapeutics, toxicity. Antimony in medicine, anti-leishmania. Bismuth and its salene complexes. Biochemistry of selenium and its importance as a trace element. 6. Titanium and Vanadium therapeutics (Ti, V) - anticancer Ti metallotherapeutics, titanocenes. Vanadium in the treatment of diabetes mellitus. Biologial activity of vanadium complexes. 7. Pharmaceuticals of 7th group (Mn, Tc, Re) - manganese metallotherapeutics, MnSOD (manganese superoxide dismutase), manganese as a trace element. Technecium and rhenium in radiopharmacy. 8. Iron triad pharmaceuticals (Fe, Co) - iron based therapeutics, ferrocenes. Cobalt complexes in chemotherapy, drug targeting - cobalamin conjugates as drug carriers. 9. Ruthenium and rhodium therapeutics (Ru, Rh) - ruthenium complexes in cancer chemotherapy. Anticancer activity of rhodium complexes, photochemotherapy. 10. Palladium therapeutics (Pd) - antiviral, antimycotic and antimicrobial activity of palladium complexes. Pd(II) complexes in cancer chemotherapy, Schiff bases as ligands. 11. Platinum therapeutics (Pt) - platinum as the most important transition metal in cancer chemotherapy, cisplatin, carboplatin, oxaliplatin. Anticancer drugs - mechanism of action. Polynulear platinum complexes, Pt(IV) compounds. A combination of platinum complexes with other therapeutics. 12. Pharmaceuticals of 11th and 12th group metals (Cu, Ag, Au, Zn) - copper chemotherapeutics, complexes with purine derivatives. Antimicrobial and antimycotic effect of silver and its compounds. Antimicrobial, anti-malaria and anti-HIV activity of gold complexes. Zinc metallotherapeutics, zinc deficiency risk factors in human body.
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Dabrowiak, J. C. (2017). Metals in Medicine. John Wiley & Sons.
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Gielen, M., Tiekink, E. R. T. (2005). Matallotherapeutic Drugs and Metal-based Diagnostic Agents. John Wiley & Sons, Ltd.
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Sigel, A., Sigel, H., Freisinger, E., Sigel, R. K. O. (2018). Metallo-Drugs: Development and Action of Anticancer Agents. De Gruyter.
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