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Lecturer(s)
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Fryčák Petr, doc. RNDr. Ph.D.
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Course content
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Toxicology - Mission and industries, history and present. Chemization and human health.Basic terms of hygienic-toxicological evaluation of chemical substances.Effects of poisons on specific receptors of organism. Corrosive, metabolic, neurotoxic, hepatotoxic and immunotoxic, mutagenic and carcinogenic toxins. Biotransformation.The most important chemical pollutants, overview of elements and their inorganic and organic compounds.Industrial toxicology.Pharmacological toxicology.Toxicology of narcotic and psychotropic substances.Plant, fungal and animal toxins.Overview and toxicology of pesticides.Toxicology of chemical warfare agents.Foreign matter in the biosphere. Toxicology of water and air; extraneous matter in soil and foodstuffs.Mutagenicity, carcinogenicity, teratogenicity.Chemical toxicological analysis.Legislative measures (Act No. 356/2003 Coll. On chemical substances and preparations, government regulations on poisons and some other substances harmful to health; guidelines for working with chemical carcinogens; issues of maximum permissible concentrations; professional standards and hygiene limits).
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Learning activities and teaching methods
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Lecture
- Attendace
- 26 hours per semester
- Preparation for the Exam
- 34 hours per semester
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Learning outcomes
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The aim is to gain a basic overview of toxicology, the basics of toxicokinetics, toxicodynamics and biotransformation and knowledge about the harmful effects of inorganic and organic compounds, the most common industrial products and intermediates, drug substances, narcotic and psychotropic substances, pesticides, chemical warfare agents and natural toxins.
Define main concepts in toxicology and hygiene, describe main toxicological properties of substances
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Prerequisites
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The knowledge of basics of general, organic, anorganic, analytical chemistry and biochemistry is recommended.
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Assessment methods and criteria
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Mark, Oral exam, Written exam
oral examination- basic facts and discussion about selected themes (e.g. dangerous of chemical compounds, interaction of a chemical compound with organism, qualitative and quantitative expression of toxicity,examples of selected poisons influence.
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Recommended literature
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Anderson K.E., Scott R., M.:Fundamentals of Industrial Toxicology (1981.
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[Anorganické látky (1980). Organické látky I, II (1986)]..
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Bardoděj Z.: Úvod do chemické toxikologie (1999)..
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Duffus J., H., Worth H.G.J.: Fundamental Toxicology for Chemists (1996)..
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Horák J., Linhart I., Klusoň P.: Úvod do toxikologie a ekologie pro chemiky (2004)..
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http://chemie.upce.cz/.
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http://www.biotox.cz/.
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Marhold J.: Přehled průmyslové toxikologie..
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Matrka M., Rusek V.:Průmyslová toxikologie - úvod do obecné a speciální toxikologie (1998)..
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Nařízení vlády č. 10.
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Paleček J., Palatý J.: Toxikologie, hygiena a bezpečnost práce v chemii (1991)..
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Patočka J.: Úvod do obecné toxikologie (2000 )..
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Prokeš J. a kol.: Základy toxikologie (2004)..
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Rusek V.: Základy toxikologie a úvod do problematiky hygieny a bezpečnosti práce v chemické laboratoři (2001).
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Směrnice č. 64 o hygienických zásadách pro práci s chemickými karcinogeny (1984, 1990)..
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Tichý M.: Toxikologie pro chemiky (2000)..
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Töllgyessy J. a kol.: Chémia, biológia a toxikologia vody a ovzdušia (1989)..
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Zákon č. 167/1998 Sb. o návykových látkách..
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Zákon č. 356/2003 Sb. o chemických látkách a přípravcích.
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