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Lecturer(s)
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Ulrichová Jitka, prof. RNDr. CSc.
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Course content
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Experimental methods used for determination of toxicity in vitro and in vivo (acute and chronic toxicity, carcinogenicity, reproductive toxicity, genotoxicity, teratogenicity, immunotoxicology, phototoxicity, excitability tests, allergy desensitization). Legislature and evaluation procedures in dependence on variety of substance used or application of sanitary technique. Legislature and ethics in work with laboratory animals, interpretation of toxicological data, alternative models supplanting testing procedures using animals. Methods and evaluation of metabolism and disposal of xenobiotics. Principles of work according to correct laboratory practice and executing of accredited tests.
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming)
- Attendace
- 20 hours per semester
- Preparation for the Exam
- 80 hours per semester
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Learning outcomes
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To obtain overview in an area of experimental toxicology.
Explain current methods and procedures used in experimental toxicology, evaluate results
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Prerequisites
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Successfully graduation master's programme Analytical chemistry.
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Assessment methods and criteria
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Oral exam
To become acquainted with the subject matter according to guarantor or teacher recommendations and prove capability to explain and discuss given topic.
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Recommended literature
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Current Protocols in Toxikology. (John Wiley Inc.), www.currentprotocols.com.
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European Centre for the Validation of Alternative Methods (ECVAM). http://ecvam.jrc.it.
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TOXNET (Toxicology Data Network). http://toxnet.nlm.nih.gov.
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Vyhláška Ministerstva zdravotnictví ČR č. 443/2004 Sb., kterou se stanoví základní metody pro zkoušení toxicity chemických látek a chemických přípravků.
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Česká technická norma ČSN EN ISO 10993. Biologické hodnocení prostředků zdravotnické techniky.
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Česká technická norma ČSN EN ISO 7405. Stomatologie - preklinické hodnocení biologické snášenlivosti prostředků zdravotnické techniky používaných ve stomatologii.
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Patočka J. Vojenská toxikologie. Grada Publishing, Praha.
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