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Lecturer(s)
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Fryčák Petr, doc. RNDr. Ph.D.
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Course content
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1. Introduction to clinical and forensic toxicology. 2. Objectives of toxicological tests. Pharmacokinetics, metabolism (absorption - distribution - elimination - accumulation of noxes). Pharmacodynamics 3. Biotransformation. Poisoning, overdose, toxic levels, Nox interaction. General approaches to the treatment of acute intoxication. 4. Laboratory diagnosis of poisoning, drug abuse, the choice of samples, detection limits and detection time window. Trends in analytical toxicology (current toxicological methods, strengths and limitations - Validation of toxicology methods) 5. Noxae in acute intoxication (Acids and bases - Metals - Gas - Volatile substances - Alcohols, glycols - Pesticides - Overdose of drugs, addictive substances - poisoning caused by plants, fungi - Drug abuse, drug addiction). 6. Alternative materials with respect to the drug identification (Saliva - Meconium - Hair) 7. Legislation in relation to substance abuse treatment 8. Practical information on acute poisoning 9. The main types of drugs and drug addiction (Cannabinoids, central stimulants, substances with central-depressant effect, Solvencia, opiates / opioids, analgesic compounds, Tobacco, Alcohol) 10. Toxicology of organic colorants (dyes and organic pigments), intermediates (starting materials and paint products). Toxicology of polymeric materials and coatings. Toxicology of other important industrial products and technical chemistry. 11. Toxicological tests - tests on animals, tests for acute toxicity, subacute toxicity, teratogenicity, subchronic toxicity, chronic toxicity. 12. The most important specific poisoning and antidotes administered
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Learning activities and teaching methods
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Lecture
- Attendace
- 26 hours per semester
- Homework for Teaching
- 13 hours per semester
- Preparation for the Exam
- 21 hours per semester
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Learning outcomes
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The goal of this course is to acquaint students with the problems of clinical toxicology, the effects of drugs, illegal substances and drugs and poisons on the human organism. Students will be acquainted with the metabolism of those substances and methods of their license and identification in body fluids and the evaluation results for forensic purposes.
The student knows the basics of clinical toxicology and is able to apply its findings and conclusions in forensic investigations. It is able to communicate with other professionals cooperating in the investigation of criminal offenses.
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Prerequisites
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The knowledge of basics of analytical chemistry and instrumental methods of analytical chemistry is recommended.
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Assessment methods and criteria
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Oral exam
To pass an exam - oral examination, 3 questions
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Recommended literature
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M. Johll: Investigating Chemistry: A Forensic Science Perspective, W. H. Freeman; Second Edition edition, USA..
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M. Johll: Investigating Chemistry: A Forensic Science Perspective, W. H. Freeman; Second Edition edition, USA..
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S. Bell: Drugs, Poisons, and Chemistry (Essentials of Forensic Science), Facts on File; 1 edition (November 2008), USA.
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S. Bell: Drugs, Poisons, and Chemistry (Essentials of Forensic Science), Facts on File; 1 edition (November 2008), USA..
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S. Bell: Forensic Chemistry, Prentice Hall; 2 edition 2012, USA..
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S. Bell: Forensic Chemistry, Prentice Hall; 2 edition 2012, USA..
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V. Vondráček, O. Riedl, Klinická toxikologie, Avicenum, 1971, Praha.
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V. Vondráček, O. Riedl, Klinická toxikologie, Avicenum, 1971, Praha.
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